This Bioengineering Research Grant proposal addresses the development of analytical and computational methodologies to model and analyze light scattering signals, which can be measured non-invasively from living cells and tissues. Light scattering plays a fundamental role in light trainsport in turbid media such as biological tissues and can provide valuable diagnostic information about the structure and composition of a tissue. Therefore, understanding tissue light scattering will help advance many modalities of optical imaging and diagnostics. However, the mechanisms of light scattering in cells and tissues are still poorly understood. We propose to develop novel analytical and numerical methods to analyze light scattering signals and identify the origins of tissue light scattering utilizing our robust computational finite-difference time-domain (FDTD) and pseudo-spectral time-domain (PSTD) modeling and our novel analytical methods. These studies will be built upon our recent development of analytical and numerical methods to describe spectral and angular properties of light scattering by inhomogeneous and non-spherical particles. The theoretical and computational studies will be accompanied by comprehensive experimental measurements of light scattering in living cells using our recently developed light scattering instrument, which provides multi-dimensional data about the light scattering.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB003682-03
Application #
7227760
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Zhang, Yantian
Project Start
2005-07-12
Project End
2009-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
3
Fiscal Year
2007
Total Cost
$213,278
Indirect Cost
Name
Northwestern University at Chicago
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
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