Fundamental to health human function is the transformation of sensory information to motor commands for adaptive behaviors such as reaching, grasping, tracking, and steering in the environment. A more complete understanding of the mechanisms that support these vital functions of the nervous system will facilitate treatment and rehabilitation when they fail to develop normally or break down through disease. Our CRCNS project takes an innovative, multidisciplinary approach to advance technology and theory on this central problem in neurobiology and medicine, drawing on the coordinated efforts in engineering, systems neuroscience and computational modeling. Specifically, we propose to integrate miniaturized radio telemetry recordings, advanced signal processing, control systems theory, adaptive motor studies and spatial behaviors. Empirical studies will employ an animal model that has evolved a highly successful adaptive sonar-guidance system, the echolocating bat. This mammal actively controls a complex of motor behaviors, guided by dynamic, 3-D spatial information extracted from acoustic signals. We will collect, analyze, and interpret behavioral and neural recordings from a free-flying echolocating bat, and this data will be used in computational models of sensorimotor feedback control and spatial navigation through complex environments. This work will direct the development of new algorithms for adaptive control in robotics and applications in neuromorphic engineering. It will also lay the foundation for a wide range of biomedical applications, such as implantable neural prostheses, ultra-lightweight low power sensors, controllers, medical tool design, and sonar-based assistive medical devices.
| Mao, Beatrice; Aytekin, Murat; Wilkinson, Gerald S et al. (2016) Big brown bats (Eptesicus fuscus) reveal diverse strategies for sonar target tracking in clutter. J Acoust Soc Am 140:1839 |
| Wright, Genevieve Spanjer; Chiu, Chen; Xian, Wei et al. (2014) Social calls predict foraging success in big brown bats. Curr Biol 24:885-9 |
| Moss, Cynthia F; Chiu, Chen; Surlykke, Annemarie (2011) Adaptive vocal behavior drives perception by echolocation in bats. Curr Opin Neurobiol 21:645-52 |
| Aytekin, Murat; Mao, Beatrice; Moss, Cynthia F (2010) Spatial perception and adaptive sonar behavior. J Acoust Soc Am 128:3788-98 |
| Chiu, Chen; Reddy, Puduru Viswanadha; Xian, Wei et al. (2010) Effects of competitive prey capture on flight behavior and sonar beam pattern in paired big brown bats, Eptesicus fuscus. J Exp Biol 213:3348-56 |
| Chiu, Chen; Xian, Wei; Moss, Cynthia F (2009) Adaptive echolocation behavior in bats for the analysis of auditory scenes. J Exp Biol 212:1392-404 |
| Aytekin, Murat; Moss, Cynthia F; Simon, Jonathan Z (2008) A sensorimotor approach to sound localization. Neural Comput 20:603-35 |
| de Cheveigne, Alain; Simon, Jonathan Z (2008) Denoising based on spatial filtering. J Neurosci Methods 171:331-9 |
| de Cheveigne, Alain; Simon, Jonathan Z (2008) Sensor noise suppression. J Neurosci Methods 168:195-202 |
| Chiu, Chen; Xian, Wei; Moss, Cynthia F (2008) Flying in silence: Echolocating bats cease vocalizing to avoid sonar jamming. Proc Natl Acad Sci U S A 105:13116-21 |
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