Simultaneous dual-isotope SPECT allows imaging of two physiological processes under identical conditions, thereby expanding the possibilities for clinical diagnosis, as well as fundamental investigation. The goal of the proposed research is to optimize, using task-specific metrics, the acquisition and processing of simultaneous Tc-99m and I-123 brain and cardiac studies, as well as Tc-99m and TI-201 cardiac studies. We will determine theoretical bounds on performance in several clinically relevant estimation tasks for both simultaneous and sequential dual-energy SPECT imaging, for several values of energy resolution, and for PET imaging. We will develop a comprehensive strategy, based on energy spectral methods and iterative reconstruction, for quantitative simultaneous Tc-99m/l-123 brain and cardiac SPECT. Our experience in dual isotope SPECT will be extended to simultaneous assessment of dopamine transporters with Tc-99m tracer using dynamic SPECT, and of dopamine receptors with l-123-IBZM. Dynamic and spectral a priori information will be used with artificial neural networks and factor analysis of dynamic sequences to obtain a robust estimate of the primary data sets for both radionuclides. We will develop a multiple-energy joint iterative reconstruction algorithm, using rapid Monte Carlo simulation of lead x-rays, scatter, cross-talk and high-energy contamination in several energy windows, to correct simultaneously for these factors in SPECT imaging of dual isotope pairs (Tc-99m/l-123, Tc-99m/TI-201). We will evaluate the improvements in task performance due to the new processing techniques using Monte Carlo simulations and physical acquisitions, and validate them, by patient studies, in the diagnosis of early idiopathic Parkinson disease (PD) and in the diagnosis of coronary artery disease. We expect that our approach will make quantitative simultaneous dualisotope imaging clinically feasible, and lead to earlier diagnosis and better monitoring of PD and to improved evaluation of suspected acute cardiac ischemia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB005876-02
Application #
7100890
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Anderson, John F
Project Start
2005-08-01
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
2
Fiscal Year
2006
Total Cost
$632,479
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
El Fakhri, Georges; Surti, Suleman; Trott, Cathryn M et al. (2011) Improvement in lesion detection with whole-body oncologic time-of-flight PET. J Nucl Med 52:347-53
Curillova, Zelmira; Yaman, Bettina F; Dorbala, Sharmila et al. (2009) Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. Eur J Nucl Med Mol Imaging 36:1603-10
Ouyang, Jinsong; Zhu, Xuping; Trott, Cathryn M et al. (2009) Quantitative simultaneous 99mTc/123I cardiac SPECT using MC-JOSEM. Med Phys 36:602-11
El Fakhri, Georges; Kardan, Arash; Sitek, Arkadiusz et al. (2009) Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J Nucl Med 50:1062-71
Trott, Cathryn M; El Fakhri, Georges (2008) Sequential and simultaneous dual-isotope brain SPECT: comparison with PET for estimation and discrimination tasks in early Parkinson disease. Med Phys 35:3343-53
Ouyang, Jinsong; El Fakhri, Georges; Moore, Stephen C (2008) Improved activity estimation with MC-JOSEM versus TEW-JOSEM in 111In SPECT. Med Phys 35:2029-40
Guerin, Bastein; Fakhri, Georges El (2008) Realistic PET Monte Carlo Simulation With Pixelated Block Detectors, Light Sharing, Random Coincidences and Dead-Time Modeling. IEEE Trans Nucl Sci 55:942-952
Ouyang, Jinsong; El Fakhri, Georges; Moore, Stephen C (2007) Fast Monte Carlo based joint iterative reconstruction for simultaneous 99mTc/ 123I SPECT imaging. Med Phys 34:3263-72
El Fakhri, Georges; Santos, Paula A; Badawi, Ramsey D et al. (2007) Impact of acquisition geometry, image processing, and patient size on lesion detection in whole-body 18F-FDG PET. J Nucl Med 48:1951-60
El Fakhri, Georges; Sitek, Arkadiusz; Zimmerman, Robert E et al. (2006) Generalized five-dimensional dynamic and spectral factor analysis. Med Phys 33:1016-24

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