Movement disorders affect over 5,000,000 people in the United States. The two most common types of movement disorders are essential tremor (ET), which affects over 4,000,000 and Parkinson's Disease (PD), which affects over 500,000 people. Contemporary treatment of these diseases involves high-frequency stimulation through deep brain stimulation (DBS). This form of therapy is offered to patients who have begun to see failure with standard medical therapy and also to patients in which medical therapy is poorly effective. A DBS procedure involves the placement, with millimetric accuracy, of an electrode in the proximity of functional areas referred to as targets. The main difficulty with the procedure is the fact that targets of interest are not or poorly visible in any imaging modality (e.g., MRI or X-ray CT). Hence, the process of implantation of a DBS electrode is an iterative procedure. An approximate target position is determined pre-operatively from the position of adjacent structures that are visible in MR images. With the patient awake, this position is then adjusted intra- operatively, which is a lengthy process. The entire procedure can take 5-6 hours, and requires expertise from a neurosurgeon, an electrophysiologist, and a neurologist. This combined expertise is only available at a limited number of centers, which is one of the reasons why only 3000 procedures are performed annually despite the much larger number of patients who could benefit from it. The goal of this project is to develop a surgical guidance systems that will assist neurosurgeons in identifying targets of interest pre-operatively and in adjusting target position intra-operatively. If successful, the outcome of this project will be a system that will reduce the duration of the procedure, increase its rate of success, and make it feasible at sites that do not have the expertise found at leading research institutions ? ? ?
| Huo, Yuankai; Bao, Shunxing; Parvathaneni, Prasanna et al. (2018) Improved Stability of Whole Brain Surface Parcellation with Multi-Atlas Segmentation. Proc SPIE Int Soc Opt Eng 10574: |
| Scharre, Douglas W; Weichart, Emily; Nielson, Dylan et al. (2018) Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease. J Alzheimers Dis 62:621-633 |
| Hu, Peijun; Huo, Yuankai; Kong, Dexing et al. (2018) Automated Characterization of Body Composition and Frailty with Clinically Acquired CT. Comput Methods Clin Appl Musculoskelet Imaging (2017) 10734:25-35 |
| Huo, Yuankai; Liu, Jiaqi; Xu, Zhoubing et al. (2018) Robust Multicontrast MRI Spleen Segmentation for Splenomegaly Using Multi-Atlas Segmentation. IEEE Trans Biomed Eng 65:336-343 |
| Jermakowicz, Walter J; Cajigas, Iahn; Dan, Lia et al. (2018) Ablation dynamics during laser interstitial thermal therapy for mesiotemporal epilepsy. PLoS One 13:e0199190 |
| Huo, Yuankai; Liu, Jiaqi; Xu, Zhoubing et al. (2017) Multi-atlas Segmentation Enables Robust Multi-contrast MRI Spleen Segmentation for Splenomegaly. Proc SPIE Int Soc Opt Eng 10133: |
| van Wouwe, N C; Pallavaram, S; Phibbs, F T et al. (2017) Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses. Neuropsychologia 99:37-47 |
| Jermakowicz, Walter J; Kanner, Andres M; Sur, Samir et al. (2017) Laser thermal ablation for mesiotemporal epilepsy: Analysis of ablation volumes and trajectories. Epilepsia 58:801-810 |
| Jermakowicz, Walter J; Ivan, Michael E; Cajigas, Iahn et al. (2017) Visual Deficit From Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy: Anatomical Considerations. Oper Neurosurg (Hagerstown) 13:627-633 |
| Bick, Sarah K B; Folley, Bradley S; Mayer, Jutta S et al. (2017) Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction. Neuromodulation 20:233-237 |
Showing the most recent 10 out of 85 publications
