Oxidative stress due to the production of reactive oxygen species is central to the cause of a variety of diseases such as cancer, neurological disorders, and rheumatological disease. It is particularly important in heart disease secondary to diabetes mellitus, a condition that is more pronounced in women than in men. Currently, we are unable to measure reactive oxygen species noninvasively within an organ such as the heart. In this grant we will develop such a method using positron emission tomography in an animal model of diabetic heart disease. The availability of this method should greatly improve our ability to understand and treat various and favorably impact human health.
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