Biofilms in the human middle-ear are known to be directly associated with chronic otitis media (OM), and the bacteria that reside within these protective biofilms are likely responsible for contributing to the persistence and re-seeding of the infection despite repeated doses of antibiotics. While prior sampling of human middle-ear biofilms was performed invasively during a surgical procedure, developments and advances in the use of innovative optical imaging technologies and systems have made it possible to non-invasively detect, characterize, and monitor any biofilm that may be affixed to the tympanic membrane and/or any effusion that may be present within the middle ear. Optical coherence tomography (OCT) has been developed for imaging applications in otolaryngology and primary care, and over the last four years, feasibility studies have demonstrated its use for imaging various tissue sites examined during a primary care exam. In this renewal project, we propose to fundamentally investigate both the clinical and biological significance of the middle-ear biofilms and effusions that are detectable with OCT systems, as well as develop low-cost solutions that will enable this technology to be economical for primary care physicians and front-line healthcare providers. Guided by a central hypothesis and five specific aims, we intend to successfully demonstrate how non-invasive OCT of the middle ear can be used to improve the clinical management of OM by identifying the presence and dynamics of biofilms and effusions in this highly prevalent disease. To accomplish our goals, we have evolved and expanded our successful bioengineering research partnership to include new world-renowned expertise in the biological and clinical investigation of middle ear biofilms, as well as a start-up company that emerged during our initial project period to fully translate and commercialize this novel technology. We expect that this new technology and its capabilities will provide new metrics for improved detection, diagnosis, and monitoring of OM. The long-term outcome and impact will be a new standard-of-care for the management of ear infections, with improved patient care.

Public Health Relevance

Ear infections (otitis media) affect nearly every child in the world, and place a significant health and economic burden on our societies. Chronic ear infections most often require surgery under anesthesia to successfully treat this disease, and bacterial biofilms in the middle ear are largely responsible for the current challenges in the disease management, which can extend over many months to several years and cost billions of dollars annually in the United States alone. Novel optical imaging technology now enables non-invasive detection, imaging, and monitoring of middle-ear biofilms and effusions, enabling new metrics to improve the diagnosis and management of this extremely common disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB013723-08
Application #
9502276
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shabestari, Behrouz
Project Start
2011-07-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
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