Supramolecular chemistry provides tools for the assembly and actuation of molecular systems. The reversibility of association of host-guest systems enables facile assembly and disassembly coupled with 'lock and key'specificity. In our proposed research we will develop new therapeutics based on intracellular host-guest actuation of nanoparticle protherapeutics. This approach provides a new strategy for the creation of bioactive materials that will enable multiple targeting strategies inaccessible with current systems. In our proposed research, we will develop new nanoparticle protherapeutics based on nanoparticle-cucurbituril (CB) host-guest complexes. These complexes dissociate inside the cell in the presence of competitive binders for CB, unmasking and activating the cytotoxic particle therapeutic. This intracellular actuation process will be quantified using mass spectrometric techniques. We will then use the unique intracellular actuation process to enable new targeting approaches, including dual-targeting strategies that are expected to be highly specific to cells overexpressing multiple receptors.
Supramolecular actuation of nanoparticle therapeutics will provide new strategies for targeted therapy.
|Gupta, Akash; Mumtaz, Shazia; Li, Cheng-Hsuan et al. (2018) Combatting antibiotic-resistant bacteria using nanomaterials. Chem Soc Rev :|
|Gupta, Akash; Das, Riddha; Yesilbag Tonga, Gulen et al. (2018) Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections. ACS Nano 12:89-94|
|Ray, Moumita; Lee, Yi-Wei; Hardie, Joseph et al. (2018) CRISPRed Macrophages for Cell-Based Cancer Immunotherapy. Bioconjug Chem 29:445-450|
|Mumtaz, Shazia; Wang, Li-Sheng; Hussain, Syed Zajif et al. (2017) Dopamine coated Fe3O4 nanoparticles as enzyme mimics for the sensitive detection of bacteria. Chem Commun (Camb) 53:12306-12308|
|Gupta, Akash; Moyano, Daniel F; Parnsubsakul, Attasith et al. (2016) Ultrastable and Biofunctionalizable Gold Nanoparticles. ACS Appl Mater Interfaces 8:14096-101|
|Jeong, Youngdo; Kim, Sung Tae; Jiang, Ying et al. (2016) Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery. Nanomedicine (Lond) 11:1571-8|
|Elci, S Gokhan; Yan, Bo; Kim, Sung Tae et al. (2016) Quantitative imaging of 2 nm monolayer-protected gold nanoparticle distributions in tissues using laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). Analyst 141:2418-25|
|Moyano, Daniel F; Liu, Yuanchang; Peer, Dan et al. (2016) Modulation of Immune Response Using Engineered Nanoparticle Surfaces. Small 12:76-82|
|Huynh, Cong Truc; Nguyen, Minh Khanh; Tonga, Gulen Yesilbag et al. (2016) Photocleavable Hydrogels for Light-Triggered siRNA Release. Adv Healthc Mater 5:305-310|
|Mizuhara, Tsukasa; Moyano, Daniel F; Rotello, Vincent M (2016) Using the Power of Organic Synthesis for Engineering the Interactions of Nanoparticles with Biological Systems. Nano Today 11:31-40|
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