The human brain is a large, well-connected, and dynamic network. Using functional MRI data, modeling how this network processes the stimulus information has yielded insight on some of the mechanisms of the brain. However, the past efforts, including ours, on using small-scale models yielded limited understanding of how the complete and dynamic neural system functions in task-related experiments. Such understanding cannot be recovered from the data without substantial and collaborative efforts on model development. Towards this goal, we formed a collaborative team from modelers to end-users, and we will develop large-scale methods for task related fMRI (tfMRI), including event-related fMRI, to model whole-brain network dynamics responding to task challenges. Using modern statistical learning principals and large-scale optimization algorithms, we will develop novel methods to model nonlinear, spatial-temporal dependence in high dimensional data of fMRI, stimuli, and behavior outcomes. We will primarily base our methods in the regularized, constrained graphical model (GM) framework, a promising multivariate framework for inferring brain connectivity that has been validated by simulation and anatomical studies. Using this framework, we will develop novel methods to investigate, at a large scale, how changes in connectivity and activation are driven by task challenges and how multiple brain pathways process stimulus information. We will perform comprehensive validation and assessment of the newly developed methods, using both simulated and multiple tfMRI data from large cohorts. Using the scale of modeling that previous approaches cannot readily address without substantial time penalties and maybe also inaccuracies, our collaborative team will also use these methods to investigate various novel questions and hypotheses concerning the neural basis for cognitive control as one of the use cases. We will also develop publicly available, open source implementations for a broad range of use in the neuroimaging community. These modeling efforts will lead to new insights on the networks of large-scale neural circuits, and provide pharmacological targets that may be overlooked using small-scale models.

Public Health Relevance

PUBLIC RELEVANCE STATEMENT We propose a foundational framework for modeling whole-brain network dynamics. Our computational approaches and algorithms will help scientists analyze a wide range of neuroimaging and behavioral data, which will lead to the capability to discover therapeutic and pharmacological targets for treating neurological and psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB022911-01
Application #
9170649
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Pai, Vinay Manjunath
Project Start
2016-09-30
Project End
2019-06-30
Budget Start
2016-09-30
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Brown University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
Chén, Oliver Y; Crainiceanu, Ciprian; Ogburn, Elizabeth L et al. (2018) High-dimensional multivariate mediation with application to neuroimaging data. Biostatistics 19:121-136
Zhang, Yihe; Zhang, Sheng; Ide, Jaime S et al. (2018) Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time. Neuroimage Clin 18:793-801
Chen, Shaojie; Liu, Kai; Yang, Yuguang et al. (2017) An M-estimator for reduced-rank system identification. Pattern Recognit Lett 86:76-81
Chen, Shaojie; Huang, Lei; Qiu, Huitong et al. (2017) Parallel group independent component analysis for massive fMRI data sets. PLoS One 12:e0173496
Zhang, Yihe; Ide, Jaime S; Zhang, Sheng et al. (2017) Distinct neural processes support post-success and post-error slowing in the stop signal task. Neuroscience 357:273-284
Kang, Jian; Caffo, Brian; Liu, Han (2016) Editorial: Recent Advances and Challenges on Big Data Analysis in Neuroimaging. Front Neurosci 10:505
Li, Shanshan; Chen, Shaojie; Yue, Chen et al. (2016) A Parcellation Based Nonparametric Algorithm for Independent Component Analysis with Application to fMRI Data. Front Neurosci 10:15