Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES000834-22
Application #
2153020
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1978-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Worcester Foundation for Biomedical Research
Department
Type
DUNS #
City
Shrewsbury
State
MA
Country
United States
Zip Code
01545
Gennings, Chris; Carrico, Caroline; Factor-Litvak, Pam et al. (2013) A cohort study evaluation of maternal PCB exposure related to time to pregnancy in daughters. Environ Health 12:66
Parte, Priyanka; Kupfer, David (2005) Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Drug Metab Dispos 33:1446-52
Hu, Y; Krausz, K; Gelboin, H V et al. (2004) CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification. Xenobiotica 34:117-32
Hazai, Eszter; Gagne, Peter V; Kupfer, David (2004) Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases. Drug Metab Dispos 32:742-51
Hu, Y; Dehal, S S; Hynd, G et al. (2003) CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes. Xenobiotica 33:141-51
Hu, Yiding; Kupfer, David (2002) Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite. Drug Metab Dispos 30:1035-42
Hu, Yiding; Kupfer, David (2002) Enantioselective metabolism of the endocrine disruptor pesticide methoxychlor by human cytochromes P450 (P450s): major differences in selective enantiomer formation by various P450 isoforms. Drug Metab Dispos 30:1329-36
Blizard, D; Sueyoshi, T; Negishi, M et al. (2001) Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. Drug Metab Dispos 29:781-5
Williams, D E; Katchamar, S; Larsen-Su, S A et al. (2001) Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions. Adv Exp Med Biol 500:635-8
Katchamart, S; Stresser, D M; Dehal, S S et al. (2000) Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in rat: implications for drug-drug interaction. Drug Metab Dispos 28:930-6

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