TheproposedAdministrativeCore(CoreA)willinteractcloselywilleachoftheproposed4projectsandthe twootherproposedcores:theScientificCoreandtheDataManagementandAnalysisCore.Wehave developedadetailedplantostrivetooptimizethesynergyandinteractionsamongtheprojects,coresand personnelinvolvedinthestudiesproposedinthisU19renewalapplication.Suchinteractionswillbefacilitated bytheexistence,atStanford,ofresourcessuchastheHumanImmuneMonitoringCore(HIMC),inwhichthe workinScientificCorewillbeconductedandwhosedirector,HoldenMaecker,isalsothedirectorofour proposedScientificCore.OtherresourcesavailabletothisU19includetheSeanN.ParkerCenterforAllergy andAsthmaResearch,whichisdirectedbyDr.KariNadeau,whoistheProject3Lead,andtheClinicaland TranslationalResearchUnit(CTRU),whichisdirectedbytheProject1Lead,Dr.SharonChinthrajah.Notably, themembersoftheStanfordteamarealreadyinteractingscientificallyunderthecurrentAADCRCU19 program.Accordingly,shouldthisrenewalapplicationbefunded,theproposedworktoadvanceour understandingofthepathologyoffoodallergy,andthemechanismsthatcontributetodesensitizationand toleranceinthisdisorder,willrepresentacontinuationandsubstantialexpansionoftheseongoing collaborativeefforts. TheAdministrativeCorehastwoSpecificAims:
Aim1 :ProvidescientificadministrationandcoordinationinsupportoftheobjectivesoftheStanfordAADCRC;? Aim2:Providefiscaloversightandadministration. AspecialfeatureofAim1isthatDr.MarkDavis,directoroftheStanfordInstituteforImmunology, Transplantation,&Infection(ITI),willco-chair,alongwiththePIoftheapplication,theScientificAdvisory BoardforthisU19,providingthegroupwiththeexpertisehehasacquiredinmanyotherhumanimmune monitoringprojectsbeingpursuedwiththeassistanceoftheHIMC(thatishousedinITI).TheScientific AdvisoryBoardalsowillincludeDr.BaliPulendran,arenownedsystemsimmunologist,andDr.AndyFire,a notedmolecularbiologistwhoalsowillbeaCo-InvestigatorinProject2.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI104209-08
Application #
10092900
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2013-07-01
Project End
2024-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
8
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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