Abstract

This grant provides core support for a broad program in the Environmental Health Sciences. The research under why and proposed is broadly relevant to adverse health effects from Environmental factors. The general objectives of the research are to define the nature and extent of such effects with the aim of instituting appropriate preventive or contral procedures where required. Interests range from acute to chronic health effects including, in the latter, cancer and the degenerative diseases. The research encompasses laboratory studies on the biochemical mode of action of environmental toxicants, exploratory studies aimed at improving the reliability and efficiency of predictive toxicological tests, improvement of diagnostic procedures for disease possibly related to environmental factors, epidemiological investigations and field studies on the distribution of pollutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES000881-18
Application #
3249446
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1982-09-29
Project End
1994-03-31
Budget Start
1991-04-01
Budget End
1994-03-31
Support Year
18
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Fang, C P; Lippmann, M; Scheuch, G et al. (1995) Effect of flow rate on aerosol bolus penetration in a hollow canine lung airway cast. Exp Lung Res 21:547-58
Lippmann, M (1994) Deposition and retention of inhaled fibres: effects on incidence of lung cancer and mesothelioma. Occup Environ Med 51:793-8
Lippmann, M (1994) Nature of exposure to chrysotile. Ann Occup Hyg 38:459-67, 408
Fang, C P; Wilson, J E; Spektor, D M et al. (1993) Effect of lung airway branching pattern and gas composition on particle deposition in bronchial airways: III. Experimental studies with radioactively tagged aerosol in human and canine lungs. Exp Lung Res 19:377-96
Cohen, B S; Sussman, R G; Lippmann, M (1993) Factors affecting distribution of airflow in a human tracheobronchial cast. Respir Physiol 93:261-78
Briant, J K; Lippmann, M (1992) Particle transport through a hollow canine airway cast by high-frequency oscillatory ventilation. Exp Lung Res 18:385-407
Cantor, J O; Keller, S; Cerreta, J M et al. (1990) The effect of 60% oxygen on air-space enlargement and cross-linked elastin synthesis in hamsters with elastase-induced emphysema. Am Rev Respir Dis 142:668-73
Lippmann, M (1990) Man-made mineral fibers (MMMF): human exposures and health risk assessment. Toxicol Ind Health 6:225-46
Lippmann, M (1990) Effects of fiber characteristics on lung deposition, retention, and disease. Environ Health Perspect 88:311-7
Briant, J K; Cohen, B S (1989) Flow distribution through human and canine airways during inhalation and exhalation. J Appl Physiol 67:1649-54

Showing the most recent 10 out of 17 publications