Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES002370-15
Application #
2153109
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1980-04-01
Project End
1997-11-30
Budget Start
1993-12-01
Budget End
1997-11-30
Support Year
15
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Pharmacy
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Oreffo, V I; Robinson, S; You, M et al. (1998) Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia. Mol Carcinog 21:37-49
Festing, M F; Lin, L; Devereux, T R et al. (1998) At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice. Genomics 53:129-36
Lin, L; Festing, M F; Devereux, T R et al. (1998) Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res 24:481-97
Malkinson, A M; Dwyer-Nield, L D; Rice, P L et al. (1997) Mouse lung epithelial cell lines--tools for the study of differentiation and the neoplastic phenotype. Toxicology 123:53-100
Banoub, R W; Fernstrom, M; Malkinson, A M et al. (1996) Enhancement of gap junctional intercellular communication by dibutyryl cyclic AMP in lung epithelial cells. Anticancer Res 16:3715-9
Malkinson, A M; You, M (1994) The intronic structure of cancer-related genes regulates susceptibility to cancer. Mol Carcinog 10:61-5
Lange-Carter, C A; Vuillequez, J J; Malkinson, A M (1993) 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer Res 53:393-400
Blumenthal, E J; Miller, A C; Stein, G H et al. (1993) Serine/threonine protein kinases and calcium-dependent protease in senescent IMR-90 fibroblasts. Mech Ageing Dev 72:13-24
Droms, K A; Hanson, L A; Malkinson, A M et al. (1993) Altered dexamethasone responsiveness and loss of growth control in tumorigenic mouse lung cell lines. Int J Cancer 53:1017-22
Malkinson, A M; Siegel, D; Forrest, G L et al. (1992) Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res 52:4752-7

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