Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES002922-13
Application #
2153212
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1982-06-01
Project End
1996-05-31
Budget Start
1994-06-01
Budget End
1996-05-31
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Duke University
Department
Pathology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Misra, U K; Shackelford, R E; Florine-Casteel, K et al. (1996) Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. J Leukoc Biol 60:784-92
Schackelford, R E; Misra, U K; Florine-Casteel, K et al. (1995) Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism. J Biol Chem 270:3475-8
Adams, D O (1994) Molecular biology of macrophage activation: a pathway whereby psychosocial factors can potentially affect health. Psychosom Med 56:316-27
Melhus, O; Koerner, T J; Adams, D O (1991) Effects of TNF alpha on the expression of class II MHC molecules in macrophages induced by IFN gamma: evidence for suppression at the level of transcription. J Leukoc Biol 49:21-8
Fan, S; Fehr, H G; Adams, D (1991) Activation of macrophages for ADCC in vitro: effects of IL-4, TNF, interferons-alpha/beta, interferon-gamma, and GM-CSF. Cell Immunol 135:78-87
Sebaldt, R J; Prpic, V; Hollenbach, P W et al. (1990) IFN-gamma potentiates the accumulation of diacylglycerol in murine macrophages. J Immunol 145:684-9
Figueiredo, F; Uhing, R J; Okonogi, K et al. (1990) Activation of the cAMP cascade inhibits an early event involved in murine macrophage Ia expression. J Biol Chem 265:12317-23
Uhing, R J; Adams, D O (1989) Molecular events in the activation of murine macrophages. Agents Actions 26:9-14
Adams, D O; Koerner, T J (1989) Gene regulation in macrophage development and activation. Year Immunol 4:159-80
Figueiredo, F; Koerner, T J; Adams, D O (1989) Molecular mechanisms regulating the expression of class II histocompatibility molecules on macrophages. Effects of inductive and suppressive signals on gene transcription. J Immunol 143:3781-6

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