Abstract

This application proposes to develop predictive models which are aimed at explaining the release of chemical agents from the surface of particles into solvents which model physiological fluids found in the lung. Aromatic and polynuclear aromatic compounds and carbon particles of various origins will be used as examples of potential chemical agents and particles. These species have been selected since organic particulate matter has current environmental significance. The predictive models will be based of measurements of surface areas, surface heterogeneities, heats of adsorption and desorption, polarities, shapes and sizes. These parameters will be measured by volumetric, microscopic, gas solid chromatographic, liquid solid chromatographic and calorimetric procedures. Liquid solid chromatography is proposed as a novel method to study the release of agents in lung physiological fluids.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003156-02
Application #
3250289
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1984-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Andreoni, K A; Kazui, M; Cameron, D E et al. (1999) Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans. Free Radic Biol Med 26:439-45
Risby, T H; Jiang, L; Stoll, S et al. (1999) Breath ethane as a marker of reactive oxygen species during manipulation of diet and oxygen tension in rats. J Appl Physiol 86:617-22
Chin, B Y; Choi, M E; Burdick, M D et al. (1998) Induction of apoptosis by particulate matter: role of TNF-alpha and MAPK. Am J Physiol 275:L942-9
Miller 3rd, E R; Appel, L J; Jiang, L et al. (1997) Association between cigarette smoking and lipid peroxidation in a controlled feeding study. Circulation 96:1097-101
Schwarz, K B; Cox, J M; Sharma, S et al. (1997) Possible antioxidant effect of vitamin A supplementation in premature infants. J Pediatr Gastroenterol Nutr 25:408-14
Foster, W M; Jiang, L; Stetkiewicz, P T et al. (1996) Breath isoprene: temporal changes in respiratory output after exposure to ozone. J Appl Physiol 80:706-10
Risby, T H; Maley, W; Scott, R P et al. (1994) Evidence for free radical-mediated lipid peroxidation at reperfusion of human orthotopic liver transplants. Surgery 115:94-101
Jakab, G J; Risby, T H; Hemenway, D R (1992) Use of physical chemistry and in vivo exposure to investigate the toxicity of formaldehyde bound to carbonaceous particles in the murine lung. Res Rep Health Eff Inst :1-39, discussion 41-9
Jakab, G J; Risby, T H; Sehnert, S S et al. (1990) Suppression of alveolar macrophage membrane-receptor-mediated phagocytosis by model particle-adsorbate complexes: physicochemical moderators of uptake. Environ Health Perspect 89:169-74
Jakab, G J; Risby, T H; Sehnert, S S et al. (1990) Suppression of alveolar macrophage membrane receptor-mediated phagocytosis by model and actual particle-adsorbate complexes. Initial contact with the alveolar macrophage membrane. Environ Health Perspect 86:337-44

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