Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003183-11
Application #
2153248
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Houston
Department
Ophthalmology
Type
Schools of Optometry/Ophthalmol
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77204
He, Lihua; Perkins, Guy A; Poblenz, Ann T et al. (2003) Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100:1022-7
Fox, D A; Poblenz, A T; He, L et al. (2003) Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection. Eur J Ophthalmol 13 Suppl 3:S44-56
Perkins, Guy A; Ellisman, Mark H; Fox, Donald A (2003) Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications. Mol Vis 9:60-73
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He, L; Poblenz, A T; Medrano, C J et al. (2000) Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J Biol Chem 275:12175-84
Soderpalm, A K; Fox, D A; Karlsson, J O et al. (2000) Retinoic acid produces rod photoreceptor selective apoptosis in developing mammalian retina. Invest Ophthalmol Vis Sci 41:937-47
Timmers, A M; Fox, D A; He, L et al. (1999) Rod photoreceptor maturation does not vary with retinal eccentricity in mammalian retina. Curr Eye Res 18:393-402
He, L; Campbell, M L; Srivastava, D et al. (1998) Spatial and temporal expression of AP-1 responsive rod photoreceptor genes and bZIP transcription factors during development of the rat retina. Mol Vis 4:32
Fox, D A; He, L; Poblenz, A T et al. (1998) Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis. Toxicol Lett 102-103:359-61
Adamus, G; Machnicki, M; Elerding, H et al. (1998) Antibodies to recoverin induce apoptosis of photoreceptor and bipolar cells in vivo. J Autoimmun 11:523-33

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