Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES003345-10A1S1
Application #
3250564
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1983-09-28
Project End
1993-03-31
Budget Start
1990-07-21
Budget End
1991-03-31
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sinsheimer, J E; Chen, R; Das, S K et al. (1993) The genotoxicity of enantiomeric aliphatic epoxides. Mutat Res 298:197-206
Tan, R S; Chu, E H; Sinsheimer, J E (1993) Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1-naphthyl ether in mouse spleen cells in vivo. Environ Mol Mutagen 22:71-7
Einisto, P; Hooberman, B H; Sinsheimer, J E (1993) Base-pair mutations caused by six aliphatic epoxides in Salmonella typhimurium TA100, TA104, TA4001, and TA4006. Environ Mol Mutagen 21:253-7
Hooberman, B H; Chakraborty, P K; Sinsheimer, J E (1993) Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella. Mutat Res 299:85-93
Das, L; Das, S K; Chu, E H et al. (1993) Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides. Mutat Res 299:19-24
Chen, R; Nguyen, P; You, Z et al. (1993) Enantioselective detoxication of optical isomers of glycidyl ethers. Chirality 5:501-4
Sinsheimer, J E; Hooberman, B H; Das, S K et al. (1992) Genotoxicity of chryseno[4,5-bcd]thiophene and its sulfone derivative. Environ Mol Mutagen 19:259-64
van den Eeckhout, E; Coene, J; Claereboudt, J et al. (1991) Comparison of the isolation of adducts of 2'-deoxycytidine and 2'-deoxyguanosine with phenylglycidyl ether by high-performance liquid chromatography on a reversed-phase column and a polystyrene-divinylbenzene column. J Chromatogr 541:317-31
Sinsheimer, J E; Giri, A K; Hooberman, B H et al. (1991) Mutagenicity in Salmonella and sister chromatid exchange in mice for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrenes. Environ Mol Mutagen 17:93-7
Giri, A K; Messerly, E A; Chakraborty, P K et al. (1990) DNA strand breaks in liver for four aliphatic epoxides in mice. Mutat Res 242:187-94

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