Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES003456-17A1
Application #
6334237
Study Section
Chemical Pathology Study Section (CPA)
Program Officer
Velazquez, Jose M
Project Start
1984-07-01
Project End
2006-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
17
Fiscal Year
2001
Total Cost
$319,674
Indirect Cost
Name
University of South Alabama
Department
Biology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Danobeitia, Juan S; Chlebeck, Peter J; Shokolenko, Inna et al. (2017) Novel Fusion Protein Targeting Mitochondrial DNA Improves Pancreatic Islet Functional Potency and Islet Transplantation Outcomes. Cell Transplant 26:1742-1754
Shokolenko, Inna N; Wilson, Glenn L; Alexeyev, Mikhail F (2016) The ""fast"" and the ""slow"" modes of mitochondrial DNA degradation. Mitochondrial DNA A DNA Mapp Seq Anal 27:490-8
Guarini, Giacinta; Kiyooka, Takahiko; Ohanyan, Vahagn et al. (2016) Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Basic Res Cardiol 111:29
Yang, Xi-Ming; Cui, Lin; White, James et al. (2015) Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion. Basic Res Cardiol 110:3
Shokolenko, Inna N; Fayzulin, Rafik Z; Katyal, Sachin et al. (2013) Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance. J Biol Chem 288:26594-605
Alexeyev, Mikhail; Shokolenko, Inna; Wilson, Glenn et al. (2013) The maintenance of mitochondrial DNA integrity--critical analysis and update. Cold Spring Harb Perspect Biol 5:a012641
Shokolenko, Inna N; Wilson, Glenn L; Alexeyev, Mikhail F (2013) Persistent damage induces mitochondrial DNA degradation. DNA Repair (Amst) 12:488-99
Yuzefovych, Larysa; Wilson, Glenn; Rachek, Lyudmila (2010) Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab 299:E1096-105
Grishko, V I; Ho, R; Wilson, G L et al. (2009) Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes. Osteoarthritis Cartilage 17:107-13
Rachek, Lyudmila I; Yuzefovych, Larysa V; Ledoux, Susan P et al. (2009) Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes. Toxicol Appl Pharmacol 240:348-54

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