The interlaminar and horizontal connectivity of the neocortex segregates its neuronal elements into local networks. The cellular mechanisms underlying cortical network activity, and the impact of local cortical network activity during sensory processing remain largely unknown. In vivo, neurons of the neocortex exhibit rhythmic, spontaneous cycles of synaptically mediated depolarization, termed UP states, followed by cessation of synaptic activity, termed DOWN states. This proposal will specifically examine the cellular basis and functional consequences of spontaneous, persistent activity during UP states in the mammalian neocortex in vivo.
The first aim of this proposal will characterize the contributions of excitation and inhibition during the spontaneous network activity of the UP state. This will be accomplished via single and paired intracellular recording, simultaneous with extracellular unit and local field potential recordings in anesthetized ferret prefrontal cortex.
The second aim of this proposal will assess the effect of this ongoing network activity upon visual responsiveness of neurons in cat visual cortex, using methods described above. The proposed plan will provide insights into the dynamic operation of intact neocortical circuits. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS052010-02
Application #
7176919
Study Section
Special Emphasis Panel (ZRG1-F02B (20))
Program Officer
Babcock, Debra J
Project Start
2006-01-16
Project End
2009-01-15
Budget Start
2007-01-16
Budget End
2008-01-15
Support Year
2
Fiscal Year
2007
Total Cost
$25,033
Indirect Cost
Name
Yale University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520