Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES003564-02S1
Application #
3250964
Study Section
Toxicology Study Section (TOX)
Project Start
1986-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Overall Medical
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Haggerty, H G; Holsapple, M P (1990) Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology 63:1-23
Kaminski, N E; Jordan, S D; Holsapple, M P (1989) Suppression of humoral and cell-mediated immune responses by carbon tetrachloride. Fundam Appl Toxicol 12:117-28
Kim, B S; Yang, K H; Haggerty, H G et al. (1989) Production of DNA single-strand breaks in unstimulated splenocytes by dimethylnitrosamine. Mutat Res 213:185-93
Kaminski, N E; Jordan, S D; Page, D et al. (1989) Suppression of humoral immune responses by dialkylnitrosamines: structure-activity relationships. Fundam Appl Toxicol 12:321-32
Haggerty, H G; Boise, L H; Jordan, S D et al. (1988) Differential effects of coadministration of aminoacetonitrile on immunosuppression and hepatotoxicity produced by dimethylnitrosamine. J Pharmacol Exp Ther 247:774-80
Kim, D H; Yang, K H; Johnson, K W et al. (1988) Role of the transfer of metabolites from hepatocytes to splenocytes in the suppression of in vitro antibody response by dimethylnitrosamine. Biochem Pharmacol 37:2765-71
Kaminski, N E; Holsapple, M P (1987) Inhibition of macrophage accessory cell function in casein-treated B6C3F1 mice. J Immunol 139:1804-10
Johnson, K W; Munson, A E; Holsapple, M P (1987) Primary cellular target responsible for dimethylnitrosamine-induced immunosuppression in the mouse. Immunopharmacology 13:47-60
Johnson, K W; Kim, D H; Munson, A E et al. (1987) Dependence on intact cells for the in vitro activation of dimethylnitrosamine to an immunosuppressive form. Mutat Res 182:211-21
Johnson, K W; Munson, A E; Kim, D H et al. (1987) Role of reactive metabolites in suppression of humoral immunity by N-nitrosodimethylamine. J Pharmacol Exp Ther 240:847-55

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