We propose to investigate effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the motor (central and peripheral) system in several species of rodents by means of a broadbased, multidisciplinary approach involving behavior, neurochemistry, neurophysiology, and neuropathology. We will screen several species of laboratory rodents for neurotoxic effects of TCDD to develop an appropriate animal model or to rule out neurotoxicity of TCDD; we will assess whether TCDD alters the ability of the neuromuscular system to repair itself following injury, and whether traumatic damage to the neuromuscular system increases its sensitivity to TCDD; and, we will investigate mechanisms of neurotoxic action of TCDD on the central nervous system and neuromuscular system in a susceptible rodent species. The results of these studies may be expected to contribute valuable information concerning this potentially major public health hazard.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004274-02
Application #
3252317
Study Section
Toxicology Study Section (TOX)
Project Start
1987-06-01
Project End
1990-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618