Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004394-04S1
Application #
3252534
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1987-08-01
Project End
1995-07-31
Budget Start
1990-09-30
Budget End
1991-07-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Mississippi State University
Department
Type
Schools of Arts and Sciences
DUNS #
075461814
City
Mississippi State
State
MS
Country
United States
Zip Code
39762
Chambers, Janice E (2008) PON1 multitasks to protect health. Proc Natl Acad Sci U S A 105:12639-40
Tang, Jun; Carr, Russell L; Chambers, Janice E (2003) The effects of repeated oral exposures to methyl parathion on rat brain cholinesterase and muscarinic receptors during postnatal development. Toxicol Sci 76:400-6
Tang, J; Carr, R L; Chambers, J E (1999) Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development. Toxicol Sci 51:265-72
Tang, J; Chambers, J E (1999) Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases. J Biochem Mol Toxicol 13:261-8
Crittenden, P L; Carr, R; Pruett, S B (1998) Immunotoxicological assessment of methyl parathion in female B6C3F1 mice. J Toxicol Environ Health A 54:1-20
Pond, A L; Chambers, H W; Coyne, C P et al. (1998) Purification of two rat hepatic proteins with A-esterase activity toward chlorpyrifos-oxon and paraoxon. J Pharmacol Exp Ther 286:1404-11
Atterberry, T T; Burnett, W T; Chambers, J E (1997) Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol Appl Pharmacol 147:411-8
Carr, R L; Chambers, J E (1996) Kinetic analysis of the in vitro inhibition, aging, and reactivation of brain acetylcholinesterase from rat and channel catfish by paraoxon and chlorpyrifos-oxon. Toxicol Appl Pharmacol 139:365-73
Pond, A L; Coyne, C P; Chambers, H W et al. (1996) Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos-oxon. Biochem Pharmacol 52:363-9
Watson, A M; Chambers, J E (1996) The effect of high and low dosages of paraoxon in beta-naphthoflavone-treated rats. J Biochem Toxicol 11:263-8

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