Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004597-03
Application #
2153699
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Gupta, Ramesh C; Milatovic, Dejan; Dettbarn, Wolf-D (2002) Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity. Arch Toxicol 76:715-26
Milatovic, Dejan; Gupta, Ramesh C; Dettbarn, Wolf D (2002) Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. Brain Res 957:330-7
Milatovic, D; Zivin, M; Gupta, R C et al. (2001) Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus. Brain Res 912:67-78
Gupta, R C; Milatovic, D; Dettbarn, W D (2001) Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants. Neurotoxicology 22:271-82
Gupta, R C; Milatovic, D; Dettbarn, W D (2001) Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E. Arch Toxicol 75:346-56
Milatovic, D; Zivin, M; Hustedt, E et al. (2000) Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat. Neurosci Lett 278:25-8
Gupta, R C; Milatovic, D; Zivin, M et al. (2000) Seizure-induced changes in energy metabolites and effects of N-tert-butyl-alpha-phenylnitrone (PNB) and vitamin E in rats. Pflugers Arch 440:R160-2
Milatovic, D; Radic, Z; Zivin, M et al. (2000) Atypical effect of some spin trapping agents: reversible inhibition of acetylcholinesterase. Free Radic Biol Med 28:597-603
Zivin, M; Milatovic, D; Dettbarn, W D (1999) Nitrone spin trapping compound N-tert-butyl-alpha-phenylnitrone prevents seizures induced by anticholinesterases. Brain Res 850:63-72
Yang, Z P; Dettbarn, W D (1998) Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy. J Physiol Paris 92:157-61

Showing the most recent 10 out of 11 publications