Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004872-08
Application #
2153808
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1988-09-19
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Elder, A; Johnston, C; Gelein, R et al. (2005) Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res 31:527-46
Oberdorster, G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1-8
Johnston, C J; Driscoll, K E; Finkelstein, J N et al. (2000) Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci 56:405-13
Johnston, C J; Oberdorster, G; Gelein, R et al. (2000) Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin. Inhal Toxicol 12:205-24
Johnston, C J; Reed, C K; Avissar, N E et al. (2000) Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice. Inhal Toxicol 12:187-203
Elder, A C; Gelein, R; Finkelstein, J N et al. (2000) Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol 12 Suppl 4:227-46
Barrett, E G; Johnston, C; Oberdorster, G et al. (1999) Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol Appl Pharmacol 161:111-22
Barrett, E G; Johnston, C; Oberdorster, G et al. (1999) Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. Am J Physiol 276:L979-88
Barrett, E G; Johnston, C; Oberdorster, G et al. (1999) Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure. Toxicol Appl Pharmacol 158:211-20
Barrett, E G; Johnston, C; Oberdorster, G et al. (1998) Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha. Am J Physiol 275:L1110-9

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