Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES005046-08
Application #
2153927
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Fleming, D E; Chettle, D R; Wetmur, J G et al. (1998) Effect of the delta-aminolevulinate dehydratase polymorphism on the accumulation of lead in bone and blood in lead smelter workers. Environ Res 77:49-61
Bergdahl, I A; Grubb, A; Schutz, A et al. (1997) Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. Pharmacol Toxicol 81:153-8
Bergdahl, I A; Gerhardsson, L; Schutz, A et al. (1997) Delta-aminolevulinic acid dehydratase polymorphism: influence on lead levels and kidney function in humans. Arch Environ Health 52:91-6
Todd, A C; Wetmur, J G; Moline, J M et al. (1996) Unraveling the chronic toxicity of lead: an essential priority for environmental health. Environ Health Perspect 104 Suppl 1:141-6
Kaya, A H; Plewinska, M; Wong, D M et al. (1994) Human delta-aminolevulinate dehydratase (ALAD) gene: structure and alternative splicing of the erythroid and housekeeping mRNAs. Genomics 19:242-8
Wetmur, J G (1994) Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden. Environ Health Perspect 102 Suppl 3:215-9
Wetmur, J G; Kaya, A H; Plewinska, M et al. (1991) Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am J Hum Genet 49:757-63
Astrin, K H; Kaya, A H; Wetmur, J G et al. (1991) RsaI polymorphism in the human delta-aminolevulinate dehydratase gene at 9q34. Nucleic Acids Res 19:4307
Wetmur, J G; Lehnert, G; Desnick, R J (1991) The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. Environ Res 56:109-19
Plewinska, M; Thunell, S; Holmberg, L et al. (1991) delta-Aminolevulinate dehydratase deficient porphyria: identification of the molecular lesions in a severely affected homozygote. Am J Hum Genet 49:167-74

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