Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES005853-04A2S1
Application #
2718473
Study Section
Special Emphasis Panel (ZRG4 (01))
Project Start
1997-09-15
Project End
2001-08-31
Budget Start
1997-09-15
Budget End
1998-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Miami Coral Gables
Department
Zoology
Type
Other Domestic Higher Education
DUNS #
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Bourdelais, Andrea J; Jacocks, Henry M; Wright, Jeffrey L C et al. (2005) A new polyether ladder compound produced by the dinoflagellate Karenia brevis. J Nat Prod 68:2-6
Bourdelais, Andrea J; Campbell, Susan; Jacocks, Henry et al. (2004) Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays. Cell Mol Neurobiol 24:553-63
Whitney, P L; Delgado, J A; Baden, D G (1997) Complex behavior of marine animal tissue extracts in the competitive binding assay of brevetoxins with rat brain synaptosomes. Nat Toxins 5:193-200
Whitney, P L; Baden, D G (1996) Complex association and dissociation kinetics of brevetoxin binding to voltage-sensitive rat brain sodium channels. Nat Toxins 4:261-70
Baden, D G; Melinek, R; Sechet, V et al. (1995) Modified immunoassays for polyether toxins: implications of biological matrixes, metabolic states, and epitope recognition. J AOAC Int 78:499-508
Gawley, R E; Rein, K S; Jeglitsch, G et al. (1995) The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol 2:533-41
Baden, D G; Rein, K S; Gawley, R E et al. (1994) Is the A-ring lactone of brevetoxin PbTx-3 required for sodium channel orphan receptor binding and activity? Nat Toxins 2:212-21
Melinek, R; Rein, K S; Schultz, D R et al. (1994) Brevetoxin PbTx-2 immunology: differential epitope recognition by antibodies from two goats. Toxicon 32:883-90