Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES006141-04A1
Application #
2154959
Study Section
Special Emphasis Panel (ZRG4-SOH (01))
Project Start
1992-08-01
Project End
1999-06-30
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Louisville
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Campian, E Cristian; Benz, Frederick W (2008) The acute lethality of acrylonitrile is not due to brain metabolic arrest. Toxicology 253:104-9
Nerland, Donald E; Cai, Jian; Benz, Frederick W (2003) Selective covalent binding of acrylonitrile to Cys 186 in rat liver carbonic anhydrase III in vivo. Chem Res Toxicol 16:583-9
Campian, E Cristian; Cai, Jian; Benz, Frederick W (2002) Acrylonitrile irreversibly inactivates glyceraldehyde-3-phosphate dehydrogenase by alkylating the catalytically active cysteine 149. Chem Biol Interact 140:279-91
Nerland, D E; Cai, J; Pierce Jr, W M et al. (2001) Covalent binding of acrylonitrile to specific rat liver glutathione S-transferases in vivo. Chem Res Toxicol 14:799-806
Reyes, G F; Corbett, D; Benz, F W et al. (2000) Acrylonitrile induces autolysis Bacillus subtilis. FEMS Microbiol Lett 182:255-8
Benz, F W; Nerland, D E; Li, J et al. (1997) Dose dependence of covalent binding of acrylonitrile to tissue protein and globin in rats. Fundam Appl Toxicol 36:149-56
Benz, F W; Nerland, D E; Corbett, D et al. (1997) Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time. Fundam Appl Toxicol 36:141-8