Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006219-03
Application #
2155084
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-06-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Zhang, J; Patel, J M; Block, E R (1998) Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells. Am J Physiol 275:L461-8
Zhang, J; Li, Y D; Patel, J M et al. (1998) Thioredoxin overexpression prevents NO-induced reduction of NO synthase activity in lung endothelial cells. Am J Physiol 275:L288-93
Zhang, J; Patel, J M; Block, E R (1997) Molecular cloning, characterization and expression of a nitric oxide synthase from porcine pulmonary artery endothelial cells. Comp Biochem Physiol B Biochem Mol Biol 116:485-91
Zhang, J; Patel, J M; Li, Y D et al. (1997) Proinflammatory cytokines downregulate gene expression and activity of constitutive nitric oxide synthase in porcine pulmonary artery endothelial cells. Res Commun Mol Pathol Pharmacol 96:71-87
Zhang, J L; Patel, J M; Li, Y D et al. (1996) Reductase domain cysteines 1048 and 1114 are critical for catalytic activity of human endothelial cell nitric oxide synthase as probed by site-directed mutagenesis. Biochem Biophys Res Commun 226:293-300
Patel, J M; Abeles, A J; Block, E R (1996) Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells. Free Radic Biol Med 20:629-37
Patel, J M; Zhang, J; Block, E R (1996) Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity. Am J Respir Cell Mol Biol 15:410-9
Patel, J M; Block, E R (1995) Sulfhydryl-disulfide modulation and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 13:352-9