Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006258-04
Application #
2155114
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Pharmacy
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Irons, Richard D; Le, Anh Tuan (2008) Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes. Chem Biol Interact 172:81-92
Gross, S A; Zheng, J H; Le, A T et al. (2006) PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34(+) hematopoietic progenitor cells. Cell Biol Toxicol 22:229-41
Zheng, J H; Pyatt, D W; Gross, S A et al. (2004) Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells. Leukemia 18:1296-304
Kerzic, Patrick J; Pyatt, David W; Zheng, Jia Hua et al. (2003) Inhibition of NF-kappaB by hydroquinone sensitizes human bone marrow progenitor cells to TNF-alpha-induced apoptosis. Toxicology 187:127-37
Irons, R D; Pyatt, D W; Gross, S A et al. (2001) Hematopoietic stem and progenitor cells as targets for biological reactive intermediates. Adv Exp Med Biol 500:441-9
Baker, R K; Kurz, E U; Pyatt, D W et al. (2001) Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha. Blood 98:830-3
Irons, R D; Stillman, W S; Pyatt, D W et al. (2001) Comparative toxicity of dithiocarbamates and butadiene metabolites in human lymphoid and bone marrow cells. Chem Biol Interact 135-136:615-25
Stillman, W S; Varella-Garcia, M; Irons, R D (2000) The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells. Exp Hematol 28:169-76
Pyatt, D W; Yang, Y; Stillman, W S et al. (2000) Hydroquinone inhibits PMA-induced activation of NFkappaB in primary human CD19+ B lymphocytes. Cell Biol Toxicol 16:41-51
Pyatt, D W; Yang, Y; Mehos, B et al. (2000) Hematotoxicity of the chinese herbal medicine Tripterygium wilfordii hook f in CD34-positive human bone marrow cells. Mol Pharmacol 57:512-8

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