Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES006263-02
Application #
3254539
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-10-01
Project End
1998-05-31
Budget Start
1993-10-01
Budget End
1994-05-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Gorman, Nadia; Trask, Heidi S; Robinson, Susan W et al. (2007) Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2. Toxicol Appl Pharmacol 221:235-42
Gorman, Nadia; Zaharia, Adrian; Trask, Heidi S et al. (2007) Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda. Hepatology 46:1927-834
Gorman, Nadia; Zaharia, Adrian; Trask, Heidi S et al. (2007) Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda. Hepatology 45:187-94
Trask, Heidi W; Gorman, Nadia; Dwyer, Barney E et al. (2005) Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures. Arch Biochem Biophys 439:1-11
Uno, Shigeyuki; Dalton, Timothy P; Sinclair, Peter R et al. (2004) Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol Appl Pharmacol 196:410-21
Grundy, Martin A; Gorman, Nadia; Sinclair, Peter R et al. (2004) High-throughput non-heme iron assay for animal tissues. J Biochem Biophys Methods 59:195-200
Gorman, Nadia; Trask, Heidi W; Bement, William J et al. (2004) Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice. Hepatology 40:942-50
Hon, Thomas; Dodd, Athena; Dirmeier, Reinhard et al. (2003) A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity. J Biol Chem 278:50771-80
Sinclair, Peter R; Gorman, Nadia; Trask, Heidi W et al. (2003) Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda. Hepatology 37:351-8
Gorman, Nadia; Ross, Kerry L; Walton, Heidi S et al. (2002) Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology 35:912-21

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