Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006321-04
Application #
2155186
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-04-07
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Nebert, Daniel W; Gálvez-Peralta, Marina; Shi, Zhanquan et al. (2010) Inbreeding and epigenetics: beneficial as well as deleterious effects. Nat Rev Genet 11:662
Greaves, Peter; Clothier, Bruce; Davies, Reginald et al. (2005) Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse. Biochem Biophys Res Commun 331:147-52
Derkenne, Sandrine; Curran, Christine P; Shertzer, Howard G et al. (2005) Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenet Genomics 15:503-11
Kleiner, Heather E; Vulimiri, Suryanarayana V; Hatten, William B et al. (2004) Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis. Chem Res Toxicol 17:1667-74
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Shertzer, Howard G; Clay, Corey D; Genter, Mary Beth et al. (2004) Cyp1a2 protects against reactive oxygen production in mouse liver microsomes. Free Radic Biol Med 36:605-17
Smith, Andrew G; Davies, Reginald; Dalton, Timothy P et al. (2003) Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse. EHP Toxicogenomics 111:45-51
Tsuneoka, Yutaka; Dalton, Timothy P; Miller, Marian L et al. (2003) 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. J Natl Cancer Inst 95:1227-37
Miller, Marian L; Andringa, Anastasia; Turner, Lloyd T et al. (2003) Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth. Microsc Res Tech 60:528-36
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