Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006414-03
Application #
2155281
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rutgers University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Iba, Michael M; Fung, Jacqueline; Chung, Le et al. (2006) Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke. Mutat Res 606:1-11
Iba, Michael M; Nguyen, Truyen; Fung, Jacqueline (2002) CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Arch Biochem Biophys 404:326-34
Iba, M M; Fung, J (2001) Pulmonary Cyp1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol 62:617-26
Wei, C; Caccavale, R J; Kehoe, J J et al. (2001) CYP1A2 is expressed along with CYP1A1 in the human lung. Cancer Lett 171:113-20
Iba, M M; Fung, J; Cooper, K R et al. (2000) Effect of gestational and lactational 2,3,7, 8-tetrachlorodibenzo-p-dioxin exposure on the level and catalytic activities of hepatic microsomal CYP1A in prepubertal and adult rats. Biochem Pharmacol 59:1147-54
Iba, M M; Fung, J; Giannone, J V et al. (2000) Comparative induction of CYP1A1 expression by pyridine and its metabolites. Arch Biochem Biophys 378:299-310
Iba, M M; Fung, J; Gonzalez, F J (2000) Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse. Arch Toxicol 74:582-6
Iba, M M; Fung, J; Thomas, P E et al. (1999) Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic. Arch Toxicol 73:208-16
Iba, M M; Fung, J (1999) Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine. Eur J Pharmacol 383:399-403
Fung, J; Thomas, P E; Iba, M M (1999) Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro. Mutat Res 438:1-12

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