Ames Mutagenicity Testing with Recombinant Human P450

Porter, Todd D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Project (R01)
• Project #: 5R01ES006420-03
• Application #: 2155288
• Study Section: Toxicology Subcommittee 2 (TOX)
• Project Start: 1992-09-29
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Kentucky
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 832127323
• City: Lexington
• State: KY
• Country: United States
• Zip Code: 40506

Publications

Cooper, M T; Porter, T D (2000) Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase. Mutat Res 454:45-52

Porter, T D; Chang, S (1999) Strategies to enhance the coexpression of cytochrome P450 2E1 and reductase in bacteria. Drug Metab Rev 31:159-74

Dong, J; Porter, T D (1996) Coexpression of mammalian cytochrome P450 and reductase in Escherichia coli. Arch Biochem Biophys 327:254-9