Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006501-04
Application #
2155352
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Biology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Govindarajan, Baskaran; Mizesko, Melissa C; Miller, Mark Steven et al. (2003) Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth. Clin Cancer Res 9:3469-75
Govindarajan, Baskaran; Klafter, Robert; Miller, Mark Steven et al. (2002) Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol Med 8:1-8
Mizesko, M C; Grewe, C; Grabner, A et al. (2001) Alterations at the Ink4a locus in transplacentally induced murine lung tumors. Cancer Lett 172:59-66
Miller, M S; Gressani, K M; Leone-Kabler, S et al. (2000) Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic amines, and lung tumor promoters. Exp Lung Res 26:709-30
Miller, M S (1999) Tumor suppressor genes in rodent lung carcinogenesis-mutation of p53 does not appear to be an early lesion in lung tumor pathogenesis. Toxicol Appl Pharmacol 156:70-7
Gressani, K M; Leone-Kabler, S; O'Sullivan, M G et al. (1999) Strain-dependent lung tumor formation in mice transplacentally exposed to 3-methylcholanthrene and post-natally exposed to butylated hydroxytoluene. Carcinogenesis 20:2159-65
Rollins, L A; Leone-Kabler, S; O'Sullivan, M G et al. (1998) Role of tumor suppressor genes in transplacental lung carcinogenesis. Mol Carcinog 21:177-84
Miller, M S; Leone-Kabler, S; Rollins, L A et al. (1998) Molecular pathogenesis of transplacentally induced mouse lung tumors. Exp Lung Res 24:557-77
Leone-Kabler, S; Wessner, L L; McEntee, M F et al. (1997) Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors. Carcinogenesis 18:1163-8
Wessner, L L; Fan, M; Schaeffer, D O et al. (1996) Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene. Carcinogenesis 17:1519-26