Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006644-03
Application #
2155450
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-07-15
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Peraza, Marjorie A; Cromey, Douglas W; Carolus, Barb et al. (2006) Morphological and functional alterations in human proximal tubular cell line induced by low level inorganic arsenic: evidence for targeting of mitochondria and initiated apoptosis. J Appl Toxicol 26:356-67
Rael, L T; Ayala-Fierro, F; Carter, D E (2000) The effects of sulfur, thiol, and thiol inhibitor compounds on arsine-induced toxicity in the human erythrocyte membrane. Toxicol Sci 55:468-77
Mitchell, R D; Ayala-Fierro, F; Carter, D E (2000) Systemic indicators of inorganic arsenic toxicity in four animal species. J Toxicol Environ Health A 59:119-34
Ayala-Fierro, F; Carter, D E (2000) LLC-PK1 cells as a model for renal toxicity caused by arsine exposure. J Toxicol Environ Health A 60:67-79
Ayala-Fierro, F; Baldwin, A L; Wilson, L M et al. (2000) Structural alterations in the rat kidney after acute arsine exposure. Lab Invest 80:87-97
Ayala-Fierro, F; Barber, D S; Rael, L T et al. (1999) In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol Sci 52:122-9
Hatlelid, K M; Carter, D E (1997) Reactive oxygen species do not cause arsine-induced hemoglobin damage. J Toxicol Environ Health 50:463-74
Winski, S L; Barber, D S; Rael, L T et al. (1997) Sequence of toxic events in arsine-induced hemolysis in vitro: implications for the mechanism of toxicity in human erythrocytes. Fundam Appl Toxicol 38:123-8
Klimecki, W T; Carter, D E (1995) Arsine toxicity: chemical and mechanistic implications. J Toxicol Environ Health 46:399-409