Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES006791-06
Application #
6469482
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Mastin, Patrick
Project Start
1996-06-04
Project End
2005-12-31
Budget Start
2002-03-12
Budget End
2002-12-31
Support Year
6
Fiscal Year
2002
Total Cost
$342,317
Indirect Cost
Name
University of California Davis
Department
Nutrition
Type
Schools of Earth Sciences/Natur
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Schelegle, Edward S; Walby, William F (2012) Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge. Respir Physiol Neurobiol 181:277-85
Oslund, Karen L; Hyde, Dallas M; Putney, Leialoha F et al. (2008) Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. Am J Respir Cell Mol Biol 39:279-88
Mansoor, Jim K; Decile, Kendra C; Giri, Shri N et al. (2007) Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma. Pulm Pharmacol Ther 20:660-8
Alfaro, Mario F; Putney, Lei; Tarkington, Brian K et al. (2004) Effect of rapid shallow breathing on the distribution of 18O-labeled ozone reaction product in the respiratory tract of the rat. Inhal Toxicol 16:77-85
Larson, Shawnessy D; Plopper, Charles G; Baker, Greg et al. (2004) Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide. Am J Physiol Lung Cell Mol Physiol 287:L286-95
Larson, Shawnessy D; Schelegle, Edward S; Walby, William F et al. (2004) Postnatal remodeling of the neural components of the epithelial-mesenchymal trophic unit in the proximal airways of infant rhesus monkeys exposed to ozone and allergen. Toxicol Appl Pharmacol 194:211-20
Schelegle, E S; Alfaro, M F; Putney, L et al. (2001) Effect of C-fiber-mediated, ozone-induced rapid shallow breathing on airway epithelial injury in rats. J Appl Physiol 91:1611-8
Schelegle, E S; Eldridge, M W; Cross, C E et al. (2001) Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects. Am J Respir Crit Care Med 163:1121-7
Sterner-Kock, A; Braun, R K; van der Vliet, A et al. (1999) Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:834-40
Vesely, K R; Schelegle, E S; Stovall, M Y et al. (1999) Breathing pattern response and epithelial labeling in ozone-induced airway injury in neutrophil-depleted rats. Am J Respir Cell Mol Biol 20:699-709