Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006811-03
Application #
2155712
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Shertzer, H G; Puga, A; Chang, C et al. (1999) Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. Chem Biol Interact 123:31-49
Maier, A; Micka, J; Miller, K et al. (1998) Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. Environ Health Perspect 106:421-6
Fitzgerald, C T; Nebert, D W; Puga, A (1998) Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors. DNA Cell Biol 17:811-22
DiRocco, L; Dalton, T; Liang, D et al. (1998) Nonallelism for the audiogenic seizure prone (Asp1) and the aryl hydrocarbon receptor (Ahr) loci in mice. J Neurogenet 12:191-203
Micka, J; Milatovich, A; Menon, A et al. (1997) Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. Pharmacogenetics 7:95-101
He, X X; Nebert, D W; Vasiliou, V et al. (1997) Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics 7:223-33
Nebert, D W (1997) Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? Am J Hum Genet 60:265-71
Nebert, D W; Duffy, J J (1997) How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Biochem Pharmacol 53:249-54
Nebert, D W; Carvan 3rd, M J (1997) Ecogenetics: from ecology to health. Toxicol Ind Health 13:163-92
Nebert, D W; McKinnon, R A; Puga, A (1996) Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA Cell Biol 15:273-80

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