Halide Catalysis of Epoxide/DNA Adduct Formation

Meehan, Thomas

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Project (R01)
• Project #: 5R01ES006869-03
• Application #: 2155793
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1994-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of California San Francisco
• Type: Schools of Pharmacy
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Wolfe, Alan R; Smith, Timothy J; Meehan, Thomas (2004) Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions. Chem Res Toxicol 17:476-91

Vock, E H; Wolfe, A R; Meehan, T (2001) Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin. Mutat Res 478:199-206

Song, Q; Negrete, G R; Wolfe, A R et al. (1998) Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol 11:1057-66

Meehan, T; Wolfe, A R; Negrete, G R et al. (1997) Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A 94:1749-54