Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006915-03
Application #
2155862
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Caruso, Rita Loch; Upham, Brad L; Harris, Craig et al. (2005) Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells. Toxicol Sci 86:417-26
Loch-Caruso, Rita; Upham, Brad L; Harris, Craig et al. (2005) Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85:694-702
Wang, Chwen-Ting; Loch-Caruso, Rita (2002) Phospholipase-mediated inhibition of spontaneous oscillatory uterine contractions by lindane in vitro. Toxicol Appl Pharmacol 182:136-47
Wang, C T; Peters-Golden, M; Loch-Caruso, R (2001) A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells. Life Sci 70:453-70
Krieger, T R; Loch-Caruso, R (2001) Antioxidants prevent gamma-hexachlorocyclohexane-induced inhibition of rat myometrial gap junctions and contractions. Biol Reprod 64:537-47
Criswell, K A; Loch-Caruso, R (1999) Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. Reprod Toxicol 13:481-90
Loch-Caruso, R (1999) A mechanistic-based approach for assessing chemical hazards to parturition. J Womens Health 8:235-48
Criswell, K A; Loch-Caruso, R; Stuenkel, E L (1995) Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messengers. Toxicol Appl Pharmacol 130:280-93
Criswell, K A; Loch-Caruso, R (1995) Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135:127-38