Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES007457-02
Application #
2156868
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Smith, Donald; Strupp, Barbara J (2013) The scientific basis for chelation: animal studies and lead chelation. J Med Toxicol 9:326-38
Beaudin, Stephane A; Stangle, Diane E; Smith, Donald R et al. (2007) Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats. Neurotoxicol Teratol 29:188-202
Stangle, Diane E; Smith, Donald R; Beaudin, Stephane A et al. (2007) Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect 115:201-9
Stangle, Diane E; Strawderman, Myla S; Smith, Donald et al. (2004) Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure. Environ Health Perspect 112:302-8
Driscoll, Lori L; Carroll, Jenna C; Moon, Jisook et al. (2004) Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. Behav Neurosci 118:1196-205
Morgan, Russell E; Garavan, Hugh P; Mactutus, Charles F et al. (2002) Enduring effects of prenatal cocaine exposure on attention and reaction to errors. Behav Neurosci 116:624-33
Cremin Jr, John D; Smith, Donald R (2002) In vitro vs in vivo Pb effects on brain protein kinase C activity. Environ Res 90:191-9
Bayer, L E; Kakumanu, S; Mactutus, C F et al. (2002) Prenatal cocaine exposure alters sensitivity to the effects of idazoxan in a distraction task. Behav Brain Res 133:185-96
Morgan, R E; Garavan, H; Smith, E G et al. (2001) Early lead exposure produces lasting changes in sustained attention, response initiation, and reactivity to errors. Neurotoxicol Teratol 23:519-31
Garavan, H; Morgan, R E; Levitsky, D A et al. (2000) Enduring effects of early lead exposure: evidence for a specific deficit in associative ability. Neurotoxicol Teratol 22:151-64

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