Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES007628-02
Application #
2157071
Study Section
Special Emphasis Panel (SRC (R))
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Liu, Jianguo; Ericksen, Spencer S; Sivaneri, Meena et al. (2004) The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism. Arch Biochem Biophys 424:33-43
Liu, Jianguo; Ericksen, Spencer S; Besspiata, Dan et al. (2003) Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382. Drug Metab Dispos 31:412-20
Kranendonk, M; Fisher, C W; Roda, R et al. (1999) Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems. Mutat Res 439:287-300
Kranendonk, M; Carreira, F; Theisen, P et al. (1999) Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies. Mutat Res 441:73-83
Shet, M S; Fisher, C W; Estabrook, R W (1997) The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17. Arch Biochem Biophys 339:218-25
Fisher, C W; Shet, M S; Estabrook, R W (1996) Construction of plasmids and expression in Escherichia coli of enzymatically active fusion proteins containing the heme-domain of a P450 linked to NADPH-P450 reductase. Methods Enzymol 272:15-25
Estabrook, R W; Shet, M S; Fisher, C W et al. (1996) The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain. Arch Biochem Biophys 333:308-15