Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES008147-01
Application #
2157591
Study Section
Special Emphasis Panel (ZRG4-ALTX-1)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Nebert, Daniel W (2017) Aryl hydrocarbon receptor (AHR): ""pioneer member"" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of ""sensors"" of foreign and endogenous signals. Prog Lipid Res 67:38-57
Lingappan, Krithika; Jiang, Weiwu; Wang, Lihua et al. (2014) Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci 141:68-77
Uno, Shigeyuki; Sakurai, Kenichi; Nebert, Daniel W et al. (2014) Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Toxicology 316:34-42
Nebert, Daniel W; Shi, Zhanquan; Gálvez-Peralta, Marina et al. (2013) Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm. Mol Pharmacol 84:304-13
Gálvez-Peralta, Marina; Shi, Zhanquan; Chen, Jing et al. (2013) Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Int J Cancer 132:2065-75
Iqbal, Jameel; Sun, Li; Cao, Jay et al. (2013) Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A 110:11115-20
Dong, Hongbin; Shertzer, Howard G; Genter, Mary Beth et al. (2013) Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem Biophys Res Commun 435:727-32
Divanovic, Senad; Dalli, Jesmond; Jorge-Nebert, Lucia F et al. (2013) Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. J Immunol 191:3347-57
Chen, Ying; Curran, Christine P; Nebert, Daniel W et al. (2012) Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicol Teratol 34:450-7
Chen, Y; Curran, C P; Nebert, D W et al. (2012) Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice. Genes Brain Behav 11:269-77

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