Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES008342-01
Application #
2157710
Study Section
Special Emphasis Panel (ZES1-CKS-B (M1))
Project Start
1996-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Milwaukee
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53201
Trewin, Amanda Louise; Woller, Michael John; Wimpee, Barbara Ann Brown et al. (2007) Short-term hormone release from adult female rat hypothalamic and pituitary explants is not altered by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Reprod Dev 53:765-75
Hutz, R J; Carvan, M J; Baldridge, M G et al. (2006) Environmental toxicants and effects on female reproductive function. Tren Reprod Bio 2:1-11
Ho, H M; Ohshima, Ken-Ichi; Watanabe, Gen et al. (2006) TCDD increases inhibin A production by human luteinized granulosa cells in vitro. J Reprod Dev 52:523-8
Baldridge, Monika G; Stahl, Rebecca L; Gerstenberger, Shawn L et al. (2004) In utero and lactational exposure of Long-Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation. Reprod Toxicol 19:155-61
Baldridge, Monika G; Stahl, Rebecca L; Gerstenberger, Shawn L et al. (2003) Modulation of ovarian follicle maturation in Long-Evans rats exposed to polychlorinated biphenyls (PCBs) in-utero and lactationally. Reprod Toxicol 17:567-73
Dasmahapatra, Asok K; Trewin, Amanda L; Hutz, Reinhold J (2002) Estrous cycle-regulated expression of CYP1B1 mRNA in the rat ovary. Comp Biochem Physiol B Biochem Mol Biol 133:127-34
Chaffin, C L; Trewin, A L; Hutz, R J (2000) Estrous cycle-dependent changes in the expression of aromatic hydrocarbon receptor (AHR) and AHR-nuclear translocator (ARNT) mRNAs in the rat ovary and liver. Chem Biol Interact 124:205-16
Dasmahapatra, A K; Wimpee, B A; Trewin, A L et al. (2000) Demonstration of 2,3,7,8-tetrachlorodibenzo-p-dioxin attenuation of P450 steroidogenic enzyme mRNAs in rat granulosa cell in vitro by competitive reverse transcriptase-polymerase chain reaction assay. Mol Cell Endocrinol 164:18-May
Heimler, I; Rawlins, R G; Owen, H et al. (1998) Dioxin perturbs, in a dose- and time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells. Endocrinology 139:4373-9
Heimler, I; Trewin, A L; Chaffin, C L et al. (1998) Modulation of ovarian follicle maturation and effects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally. Reprod Toxicol 12:69-73

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