Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES008668-02
Application #
2608523
Study Section
Special Emphasis Panel (ZES1-CKS-B (02))
Project Start
1996-12-01
Project End
1999-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Habib, Geetha M (2010) Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. J Cell Biochem 110:363-71
Habib, Geetha M (2009) p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells. Arch Biochem Biophys 481:101-9
Habib, Geetha M; Shi, Zheng-Zheng; Lieberman, Michael W (2007) Glutathione protects cells against arsenite-induced toxicity. Free Radic Biol Med 42:191-201
Valverde, Mahara; Rojas, Emilio; Kala, Subbarao V et al. (2006) Survival and cell death in cells constitutively unable to synthesize glutathione. Mutat Res 594:172-80
Rojas, E; Shi, Z-Z; Valverde, M et al. (2003) Cell survival and changes in gene expression in cells unable to synthesize glutathione. Biofactors 17:13-9
Shi, Z Z; Osei-Frimpong, J; Kala, G et al. (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A 97:5101-6
Habib, G M; Lieberman, M W (1999) Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Adv Exp Med Biol 469:295-300
Habib, G M; Cuevas, A A; Barrios, R et al. (1999) Mouse leukotriene A4 hydrolase is expressed at high levels in intestinal crypt cells and splenic lymphocytes. Gene 234:249-55
Carter, B Z; Shi, Z Z; Barrios, R et al. (1998) gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. J Biol Chem 273:28277-85
Habib, G M; Shi, Z Z; Cuevas, A A et al. (1998) Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A 95:4859-63