A Novel Endocrine Disrupting Agent and Breast Cancer

Markaverich, Barry Matthew

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Project (R01)
• Project #: 5R01ES009964-03
• Application #: 6382314
• Study Section: Reproductive Endocrinology Study Section (REN)
• Program Officer: Heindel, Jerrold
• Project Start: 1999-09-30
• Project End: 2003-09-21
• Budget Start: 2001-09-30
• Budget End: 2003-09-21
• Support Year: 3
• Fiscal Year: 2001
• Total Cost: $226,977

Institution

• Name: Baylor College of Medicine
• Department: Anatomy/Cell Biology
• Type: Schools of Medicine
• DUNS #: 074615394
• City: Houston
• State: TX
• Country: United States
• Zip Code: 77030

Publications

Shoulars, Kevin; Rodriguez, Mary Ann; Thompson, Trellis et al. (2010) Regulation of cell cycle and RNA transcription genes identified by microarray analysis of PC-3 human prostate cancer cells treated with luteolin. J Steroid Biochem Mol Biol 118:41-50

Shoulars, Kevin; Rodriguez, Mary Ann; Thompson, Trellis et al. (2008) Regulation of the nitric oxide pathway genes by tetrahydrofurandiols: microarray analysis of MCF-7 human breast cancer cells. Cancer Lett 264:265-73

Markaverich, Barry M; Crowley, Jan; Rodriquez, Mary et al. (2007) Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. Environ Health Perspect 115:1727-31

Markaverich, Barry M; Alejandro, Mary; Thompson, Trellis et al. (2007) Tetrahydrofurandiols (THF-diols), leukotoxindiols (LTX-diols), and endocrine disruption in rats. Environ Health Perspect 115:702-8

Markaverich, Barry M; Shoulars, Kevin; Alejandro, Mary-Ann (2006) Nuclear type II [3H]estradiol binding site ligands: inhibition of ER-positive and ER-negative cell proliferation and c-Myc and cyclin D1 gene expression. Steroids 71:865-74

Shoulars, Kevin; Rodriguez, Mary Ann; Crowley, Jan et al. (2006) Reconstitution of the type II [3H]estradiol binding site with recombinant histone H4. J Steroid Biochem Mol Biol 99:1-8

Shoulars, Kevin; Rodrigues, Mary Ann; Crowley, Jan R et al. (2005) Nuclear type II [3H]estradiol binding sites: a histone H3-H4 complex. J Steroid Biochem Mol Biol 96:19-30

Markaverich, Barry M; Crowley, Jan R; Alejandro, Mary A et al. (2005) Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation. Environ Health Perspect 113:1698-704

Mani, Shaila K; Reyna, Andrea M; Alejandro, Mary A et al. (2005) Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF-diols). Steroids 70:750-4

Markaverich, Barry M; Alejandro, Mary Ann; Markaverich, David et al. (2002) Identification of an endocrine disrupting agent from corn with mitogenic activity. Biochem Biophys Res Commun 291:692-700