The overall goal of this proposal is to elucidate the role of physical environmental determinants and psychosocial factors (in particular, life stress) in the rising asthma burden, particularly among socioeconomically disadvantaged children in inner city areas. The investigators' underlying concept is that stress experienced prenatally and during infancy and early childhood has significant potential to modify immune function and, hence, the development of asthma. They propose to examine the associations between various measures of life stress and asthma outcomes in a representative sample of urban children enrolled prenatally and followed prospectively for four years. Five hundred mother-infant pairs will be recruited from four participating community health centers serving ethnically diverse, inner city neighborhoods of Boston. They will complete a multilevel perspective survey, measuring both individual-level stress (i.e., negative life events, perceived stress, perceived threat of violence) and community-level stressors (neighborhood disadvantage (e.g., percent of subjects living in poverty, percent unemployed, diminished social capital and violent crime). In addition to examining associations between chronic early stress exposure and asthma onset, they will also assess the influence of stress on the infant hormonal stress response and on T-helper cell differentiation as reflected in cytokine profiles and IgE production (Th2 phenotype). Additional environmental and host factors to be assessed for their influence on the immune response and expression of asthma include parental asthma, acute lower respiratory illness, day care, environmental tobacco smoke, indoor allergens, gender, and race. The study will be conducted through a partnership involving researchers from Harvard's Longwood Medical Area, clinicians and care-providers from four community health centers serving the target population, and community advisors recruited through the health centers. A secondary, yet centrally important goal of the project is to strengthen and build this partnership to facilitate future research. This will be achieved through a clinical database project. An additional feature of the proposal is the opportunity to involve under represented minority students (predoctoral and summer interns) from two NIH-funded grants whose principal investigator is a co-investigator on this proposal.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES010932-05
Application #
6783424
Study Section
Special Emphasis Panel (ZES1-JPM-B (HD))
Program Officer
Gray, Kimberly A
Project Start
2000-09-30
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
5
Fiscal Year
2004
Total Cost
$601,265
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Lee, Alison G; Le Grand, Blake; Hsu, Hsiao-Hsien Leon et al. (2018) Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respir Res 19:76
Lee, Alison; Leon Hsu, Hsiao-Hsien; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. J Allergy Clin Immunol 141:1880-1886
Lee, Alison G; Chiu, Yueh-Hsiu M; Rosa, Maria J et al. (2017) Association of prenatal and early childhood stress with reduced lung function in 7-year-olds. Ann Allergy Asthma Immunol 119:153-159
Rosa, Maria José; Pajak, Ashley; Just, Allan C et al. (2017) Prenatal exposure to PM2.5 and birth weight: A pooled analysis from three North American longitudinal pregnancy cohort studies. Environ Int 107:173-180
Brunst, Kelly J; Rosa, Maria José; Jara, Calvin et al. (2017) Impact of Maternal Lifetime Interpersonal Trauma on Children's Asthma: Mediation Through Maternal Active Asthma During Pregnancy. Psychosom Med 79:91-100
Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon; Wilson, Ander et al. (2017) Prenatal particulate air pollution exposure and body composition in urban preschool children: Examining sensitive windows and sex-specific associations. Environ Res 158:798-805
Bose, Sonali; Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon et al. (2017) Prenatal Nitrate Exposure and Childhood Asthma. Influence of Maternal Prenatal Stress and Fetal Sex. Am J Respir Crit Care Med 196:1396-1403
Wilson, Ander; Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon et al. (2017) Potential for Bias When Estimating Critical Windows for Air Pollution in Children's Health. Am J Epidemiol 186:1281-1289
Chiu, Yueh-Hsiu Mathilda; Sheffield, Perry E; Hsu, Hsiao-Hsien Leon et al. (2017) Subconstructs of the Edinburgh Postnatal Depression Scale in a multi-ethnic inner-city population in the U.S. Arch Womens Ment Health 20:803-810

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