Abstract

The mechanisms of optic nerve disease are under investigation with experimental models in primates. Glaucomatous damage to the optic nerve is being investigated by studying the effects of elevated intraocular pressure on axonal transport, blood flow, and oxidative metabolism in the optic nerve head. Pertinent anatomic studies of the glia, blood vessels, and nerve fiber bundles are also being done. Histologic and angiographic methods are being used to study optic atrophy of the descending and ascending types. Simiar studies on the effects of intracranial pressure are being conducted to explore the mechanisms of papilledema.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000031-16
Application #
3255073
Study Section
(VID)
Project Start
1977-11-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101

  Publications

Ferrari-Dileo, G; Davis, E B; Anderson, D R (1996) Glaucoma, capillaries and pericytes. 3. Peptide hormone binding and influence on pericytes. Ophthalmologica 210:269-75
Anderson, D R; Davis, E B (1996) Glaucoma, capillaries and pericytes. 2. Identification and characterization of retinal pericytes in culture. Ophthalmologica 210:263-8
Ferrari-Dileo, G; Davis, E B; Anderson, D R (1992) Effects of cholinergic and adrenergic agonists on adenylate cyclase activity of retinal microvascular pericytes in culture. Invest Ophthalmol Vis Sci 33:42-7
Ferrari-Dileo, G; Davis, E B; Anderson, D R (1991) Angiotensin II binding receptors in retinal and optic nerve head blood vessels. An autoradiographic approach. Invest Ophthalmol Vis Sci 32:21-6
Ferrari-Dileo, G; Davis, E B; Anderson, D R (1991) Cholinergic binding sites in pericytes isolated from retinal capillaries. Blood Vessels 28:542-6
Grajewski, A L; Ferrari-Dileo, G; Feuer, W J et al. (1991) Beta-adrenergic responsiveness of choroidal vasculature. Ophthalmology 98:989-95
Ferrari-Dileo, G; Davis, E B; Anderson, D R (1990) Response of retinal vasculature to phenylephrine. Invest Ophthalmol Vis Sci 31:1181-2
Anderson, D R (1989) Glaucoma: the damage caused by pressure. XLVI Edward Jackson memorial lecture. Am J Ophthalmol 108:485-95
Ferrari-Dileo, G; Davis, E B; Anderson, D R (1989) Biochemical evidence for cholinergic activity in retinal blood vessels. Invest Ophthalmol Vis Sci 30:473-7
Ferrari-Dileo, G; Ryan, J W; Rockwood, E J et al. (1988) Angiotensin-converting enzyme in bovine, feline, and human ocular tissues. Invest Ophthalmol Vis Sci 29:876-81

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