Abstract

We plan to continue our development of quantitative theoretical methods for study of the dynamics of the visual nervous system. These methods are a blend of modern applied analysis and computer techniques. We will continue to develop these procedures in close conjunction with experimental work. As applied to the eye of the horseshoe crab our theoretical methodology has reached a mature state; our intention is to extend it to vertebrate visual systems. Our approach involves three parts: The reduction of laboratory data, the use of those reduced data to formulate dynamical equations which summarize the behavior of the piece of nervous system under investigation, and the deduction of consequences from those equations to be compared against further experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001428-12
Application #
3255955
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1977-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
12
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Rockefeller University
Department
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Zemon, Vance; Gordon, James (2006) Luminance-contrast mechanisms in humans: visual evoked potentials and a nonlinear model. Vision Res 46:4163-80
Benardete, E A; Kaplan, E (1999) The dynamics of primate M retinal ganglion cells. Vis Neurosci 16:355-68
Benardete, E A; Kaplan, E (1999) Dynamics of primate P retinal ganglion cells: responses to chromatic and achromatic stimuli. J Physiol 519 Pt 3:775-90
Mukherjee, P; Kaplan, E (1998) The maintained discharge of neurons in the cat lateral geniculate nucleus: spectral analysis and computational modeling. Vis Neurosci 15:529-39
Benardete, E A; Kaplan, E (1997) The receptive field of the primate P retinal ganglion cell, I: Linear dynamics. Vis Neurosci 14:169-85
Benardete, E A; Kaplan, E (1997) The receptive field of the primate P retinal ganglion cell, II: Nonlinear dynamics. Vis Neurosci 14:187-205
Zemon, V; Hartmann, E E; Gordon, J et al. (1997) An electrophysiological technique for assessment of the development of spatial vision. Optom Vis Sci 74:708-16
Levine, M W; Cleland, B G; Mukherjee, P et al. (1996) Tailoring of variability in the lateral geniculate nucleus of the cat. Biol Cybern 75:219-27
Mukherjee, P; Kaplan, E (1995) Dynamics of neurons in the cat lateral geniculate nucleus: in vivo electrophysiology and computational modeling. J Neurophysiol 74:1222-43
Edwards, D P; Purpura, K P; Kaplan, E (1995) Contrast sensitivity and spatial frequency response of primate cortical neurons in and around the cytochrome oxidase blobs. Vision Res 35:1501-23

Showing the most recent 10 out of 38 publications