Our overall objective is to gain an understanding of the mechanism(s) by which the pigment epithelium (PE) supports the normal functioning of the neural retina. This ultimate goal can be reformulated into the following immediate goals: to obtain a greater understanding of PE ion and metabolite transport; to assess the contribution of potassium to electroretinogram slow waves and to long-term changes in the standing potential; to determine if the PE buffers extracellular potassium; to assess PE involvement in spreading depression of the inner retina; to determine if the PE interacts with the cones in the same way that it interacts with the rods; to obtain an understanding of the passive and active ionic mechanisms of mammalian PE; to describe hormonal control of disc shedding and phagocytosis in Xenopus. It is proposed to study these PE mechanisms and PE retina interactions with a combined electrophysiological, epithelial-transport and anatomical approach.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001429-12
Application #
3255961
Study Section
(VID)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Cao, W; Li, F; Steinberg, R H et al. (2001) Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp Eye Res 72:591-604
Dmitriev, A V; Govardovskii, V I; Schwahn, H N et al. (1999) Light-induced changes of extracellular ions and volume in the isolated chick retina-pigment epithelium preparation. Vis Neurosci 16:1157-67
Li, F; Cao, W; Steinberg, R H et al. (1999) Basic FGF-induced down-regulation of IGF-I mRNA in cultured rat Muller cells. Exp Eye Res 68:19-27
LaVail, M M; Yasumura, D; Matthes, M T et al. (1998) Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39:592-602
Cheng, T; Cao, W; Wen, R et al. (1998) Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest Ophthalmol Vis Sci 39:581-91
Cao, W; Li, F; Steinberg, R H et al. (1998) Induction of c-fos and c-jun mRNA expression by basic fibroblast growth factor in cultured rat Muller cells. Invest Ophthalmol Vis Sci 39:565-73
Wen, R; Cheng, T; Song, Y et al. (1998) Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina. Curr Eye Res 17:494-500
Cao, W; Wen, R; Li, F et al. (1997) Induction of basic fibroblast growth factor mRNA by basic fibroblast growth factor in Muller cells. Invest Ophthalmol Vis Sci 38:1358-66
LaVail, M M; Matthes, M T; Yasumura, D et al. (1997) Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. Exp Eye Res 65:45-50
Cao, W; Wen, R; Li, F et al. (1997) Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp Eye Res 65:241-8

Showing the most recent 10 out of 64 publications