This is a proposal for the continuation of the study of models, or explanations of changes in sensitivity in normal and abnormal visual systems. A number of psychophysical techniques are employed including a measure of suprathreshold activity, the probe-flash technique. Using these psychophysical techniques, we propose to test explanations for changes in sensitivity due to adaptation, retinal locus, and retinal disease. The laboratory studies include the examination of dynamic and steady state adaptation of the blue/yellow system. This system offers a number of advantages for answering basic questions. In the clinic, we have found that the probe-flash paradigm can be used to test alternative explanations for retinal disease. This technique will be used in conjunction with other standard psychophysical techniques to test alternative explanations for a variety of heredoretinal degenerative diseases, including retinitis pigmentosa. Another interest is the vulnerability of the blue cone system to retinal disease. There are a number of hypotheses for this vulnerability and many of these can be tested psychophysically. Finally, we intend to obtain a better understanding of the relative involvement of the rod and different cone mechanisms in retinitis pigmentosa and in progressive cone dystrophy.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002115-15
Application #
3256516
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1977-08-01
Project End
1992-07-31
Budget Start
1991-08-01
Budget End
1992-07-31
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Other Domestic Higher Education
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Hood, Donald C; De Moraes, Carlos Gustavo (2018) Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields. Invest Ophthalmol Vis Sci 59:788-791
Wu, Zhichao; Weng, Denis S D; Rajshekhar, Rashmi et al. (2018) Effectiveness of a Qualitative Approach Toward Evaluating OCT Imaging for Detecting Glaucomatous Damage. Transl Vis Sci Technol 7:7
De Moraes, Carlos Gustavo; Muhammad, Hassan; Kaur, Khushmit et al. (2018) Interindividual Variations in Foveal Anatomy and Artifacts Seen on Inner Retinal Probability Maps from Spectral Domain OCT Scans of the Macula. Transl Vis Sci Technol 7:4
Mavrommatis, Maria A; Wu, Zhichao; Naegele, Saskia I et al. (2018) Deep Defects Seen on Visual Fields Spatially Correspond Well to Loss of Retinal Nerve Fiber Layer Seen on Circumpapillary OCT Scans. Invest Ophthalmol Vis Sci 59:621-628
Hood, Donald C; De Moraes, Carlos G (2018) Four Questions for Every Clinician Diagnosing and Monitoring Glaucoma. J Glaucoma 27:657-664
Wu, Zhichao; Weng, Denis S D; Thenappan, Abinaya et al. (2018) Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography. Transl Vis Sci Technol 7:11
Alhadeff, Paula A; De Moraes, Carlos G; Chen, Monica et al. (2017) The Association Between Clinical Features Seen on Fundus Photographs and Glaucomatous Damage Detected on Visual Fields and Optical Coherence Tomography Scans. J Glaucoma 26:498-504
Muhammad, Hassan; Fuchs, Thomas J; De Cuir, Nicole et al. (2017) Hybrid Deep Learning on Single Wide-field Optical Coherence tomography Scans Accurately Classifies Glaucoma Suspects. J Glaucoma 26:1086-1094
Prager, Alisa J; Hood, Donald C; Liebmann, Jeffrey M et al. (2017) Association of Glaucoma-Related, Optical Coherence Tomography-Measured Macular Damage With Vision-Related Quality of Life. JAMA Ophthalmol 135:783-788
Thenappan, Abinaya; De Moraes, Carlos Gustavo; Wang, Diane L et al. (2017) Optical Coherence Tomography and Glaucoma Progression: A Comparison of a Region of Interest Approach to Average Retinal Nerve Fiber Layer Thickness. J Glaucoma 26:473-477

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