Abstract

The major thrust of this study continues to be the epidemiology and clinical expression of Chlamydia trachomatis infection in our population with a focus on perinatal infections. We intend to evaluate the efficacy of erythromycin in preventing the transmission of C. trachomatis from the infected pregnant woman to her newborn infant. Through serologic surveys and chlamydial isolation attempts we will try to determine if there is any clinical expression of the seroconversions that have been demonstrated for C. trachomatis in older children (ages 5 through 10) and attempt to evaluate the contribution C. trachomatis may make to respiratory disease, particularly pneumonia in adults.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002216-09
Application #
3256593
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1978-05-01
Project End
1988-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Crombleholme, W R; Schachter, J; Grossman, M et al. (1990) Amoxicillin therapy for Chlamydia trachomatis in pregnancy. Obstet Gynecol 75:752-6
Shafer, M A; Schachter, J; Moscicki, A B et al. (1989) Urinary leukocyte esterase screening test for asymptomatic chlamydial and gonococcal infections in males. JAMA 262:2562-6
Walters, M D; Eddy, C A; Gibbs, R S et al. (1988) Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. Am J Obstet Gynecol 159:942-6
Dattel, B J; Landers, D V; Coulter, K et al. (1988) Isolation of Chlamydia trachomatis from sexually abused female adolescents. Obstet Gynecol 72:240-2
Buus, D R; Pflugfelder, S C; Schachter, J et al. (1988) Lymphogranuloma venereum conjunctivitis with a marginal corneal perforation. Ophthalmology 95:799-802
Schachter, J; Moncada, J; Dawson, C R et al. (1988) Nonculture methods for diagnosing chlamydial infection in patients with trachoma: a clue to the pathogenesis of the disease? J Infect Dis 158:1347-52
Moncada, J V; Schachter, J; Golbus, M S (1987) Chlamydia trachomatis infection among patients undergoing chorionic villus sampling. Am J Obstet Gynecol 156:915-6
Gibbs, R S; Schachter, J (1987) Chlamydial serology in patients with intra-amniotic infection and controls. Sex Transm Dis 14:213-5
Hellstrom, W J; Schachter, J; Sweet, R L et al. (1987) Is there a role for Chlamydia trachomatis and genital mycoplasma in male infertility? Fertil Steril 48:337-9
Schachter, J; Martin, D H (1987) Failure of multiple passages to increase chlamydial recovery. J Clin Microbiol 25:1851-3

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